Implementation of Area Efficient Multiple Passband FIR Filter for 5G Applications

971-978In television, mobile and digital signal processing applications, efficient multiband filters have great usage. The proposed architecture gives the Reconfigurable Finite Impulse Response (FIR) filter with multiple pass bands. Implementation of architecture utilizes FIR filter with control logic and frequency selection circuit. By adjusting the parameters of the filter, proper bandwidth of the pass band can be achieved and the ripple content in the pass band and stop band can be controlled. The efficient way to adjust the bandwidth is to choose the effective value of the filter length and coefficients. The area efficient multiple passband FIR filter using control logic has been proposed with order (n = 4 and 11). Target device that has been selected for implementation is Field Programmable Gate Array (FPGA) Virtex 4 Device. The Look-Up Tables (LUT) utilization for the implemented architecture with length of filter (n = 11) is observed to be 6%

Implementation of Area Efficient Multiple Passband FIR Filter for 5G Applications

In television, mobile and digital signal processing applications, efficient multiband filters have great usage. The proposed architecture gives the Reconfigurable Finite Impulse Response (FIR) filter with multiple pass bands. Implementation of architecture utilizes FIR filter with control logic and frequency selection circuit. By adjusting the parameters of the filter, proper bandwidth of the pass band can be achieved and the ripple content in the pass band and stop band can be controlled. The efficient way to adjust the bandwidth is to choose the effective value of the filter length and coefficients. The area efficient multiple passband FIR filter using control logic has been proposed with order (n = 4 and 11). Target device that has been selected for implementation is Field Programmable Gate Array (FPGA) Virtex 4 Device. The Look-Up Tables (LUT) utilization for the implemented architecture with length of filter (n = 11) is observed to be 6%

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

There is a significant unmet medical need for more efficacious and rapidly acting antidepressants. Toward this end, negative allosteric modulators of the <i>N</i>-methyl-d-aspartate receptor subtype GluN2B have demonstrated encouraging therapeutic potential. We report herein the discovery and preclinical profile of a water-soluble intravenous prodrug BMS-986163 (<b>6</b>) and its active parent molecule BMS-986169 (<b>5</b>), which demonstrated high binding affinity for the GluN2B allosteric site (<i>K</i>_i = 4.0 nM) and selective inhibition of GluN2B receptor function (IC₅₀ = 24 nM) in cells. The conversion of prodrug <b>6</b> to parent <b>5</b> was rapid in vitro and in vivo across preclinical species. After intravenous administration, compounds <b>5</b> and <b>6</b> have exhibited robust levels of ex vivo GluN2B target engagement in rodents and antidepressant-like activity in mice. No significant off-target activity was observed for <b>5</b>, <b>6</b>, or the major circulating metabolites <b>met-1</b> and <b>met-2</b>. The prodrug BMS-986163 (<b>6</b>) has demonstrated an acceptable safety and toxicology profile and was selected as a preclinical candidate for further evaluation in major depressive disorder